Damn! I have been trying to write this post all day, but due to my computer giving me a hard time I haven't been able to get logged in to word press and type this baby up. Talke about a frustrating afternoon, but no worries I got it figured out!

Well hope everyone out their is having a great week so far. Mine started off a bit rocky, but things are looking up for the end of the week. Remember no bad days only good days and great days. Gosh I love that saying I have to thank Alwyn and Rachel Cosgrove for that one.

Anyways I am still looking for online clients and would be happy to hear from anyone who is possibly interested. You can go here or click on the floating Facebook icon to message me and get in contact about coaching.

Otherwise here is this week's study of the week, which is actually a review talking about obesity and the effects it has on a group of hormones that may be limiting your ability to get rid of fat. Hope you enjoy it and if you get bogged down simply skip to the bottom and read the quick take away I provide.

Title

Catecholamines and Obesity: Effects of Exercise and Training

by Zouhal, Lemoine-Morel, Mathieu, Casazza, and Jabbour

published 2013 in Sports Medicine

The Review

Research has indicated that imbalances in lipid storage and oxidation can be a relevant indicator to the development of obesity. A number of hormones can affect an individual's lipid metabolism. Hormones such as insulin, cortisol, growth hormone, catecholamines, and many others. Particularly important to this review are the catecholamines, which are able to stimulate or inhibit lipolysis through several linked mechanisms leading to increased or decreased activation of lipase. Reviewers note that obesity appears to change the effects of catecholamines on fat tissue, which can cause increased adipose fat storage. In addition the anatomical site of this adipose tissue storage appears to influence the degree to which catecholamines alter lipolysis. Reviewers state that there is greater sensitivity to catecholamine stimulated lipolysis observed in subcutaneous abdominal fat tissue compared to femoral fat tissue.

According to the reviewers catecholamines are secreted from the adrenal medulla located above the kidneys, but they are also synthesized when there is a sympathetic nervous system response. The reviewers note that research has found serum catecholamine responses to be significantly less in obese people than normal people. Reviewers state that catecholamines are confirmed to stimulate lipolysis through the beta 1 and 2 adrenoreceptors, which enhance intracellular cAMP leading to phosphorylation and thus activation of lipase.

The reviewers state that acute inhibition of the sympathetic nervous system leads to increased food intake as well as a decrease in resting energy expenditure.

Reviewers say that obese individuals display a greater tendency for lipase inhibition and reduced catecholamine activation of lipase. The reviewers noted that studies have found a proportionality between lipase inhibition and the degree of obesity. In addition they stated that lipolytic response to physical exercise is reduced in obese subjects.

Reviewers inform us that studies have been reporting blunted adrenal medulla function and reduced catecholamine secretion in obese people, which may result in higher levels of serum leptin.

Conclusion

Reviewers concluded that catecholamines are important role players in regulating lipolytic activity and thus obesity plays a role in regulating the lipolytic activity due to the effects it can have on catecholamines.

Take Away

Okay this one went a bit deep in to the hormonal regulation of lipolysis, even for me and I am suppose to be a biochemistry major so don't feel bad if a lot of what I shared didn't make much sense. It is actually much simpler that what the reviewers wrote it up to be. Simply being obese is detrimental to your bodies ability to synthesize a particular group of hormones known as catecholamines and these hormones play important roles in helping you oxidize and get rid of fat. And based on the current body of evidence obesity seems to negatively affect catecholamine production which prevents you from having the proper hormonal response to physical exercise and while at rest resulting in a less than optimal ability to burn fat. So while losing fat is our ultimate goal, for obese people it could be mutually beneficial to work on losing a bit of weight to improve their fat burning ability.

Practical, Purposeful, Effective Training